Targeting the Tumor Stroma for Oral Cancer Therapy
نویسندگان
چکیده
منابع مشابه
Emerging concepts in pancreatic cancer medicine: targeting the tumor stroma
Pancreatic ductal adenocarcinoma is a stroma-rich and highly challenging cancer to treat. Over recent years, it has become increasingly evident that the complex network of soluble cytokines, growth factors, proteases, and components of the extracellular matrix collaboratively interact within the tumor microenvironment, sustaining and driving cancer cell proliferation, invasion, and early metast...
متن کاملTargeting the tumor microenvironment for cancer therapy.
BACKGROUND With the emergence of the tumor microenvironment as an essential ingredient of cancer malignancy, therapies targeting the host compartment of tumors have begun to be designed and applied in the clinic. CONTENT The malignant features of cancer cells cannot be manifested without an important interplay between cancer cells and their local environment. The tumor infiltrate composed of ...
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چکیده ندارد.
15 صفحه اولCancer Therapy: Preclinical Targeting the Notch Ligand Jagged1 in Both Tumor Cells and Stroma in Ovarian Cancer
Purpose: Jagged1, a Notch ligand, is expressed on both tumor epithelial and endothelial cells and therefore may be amenable to dual targeting of the tumor stroma and malignant cell compartments of the tumor microenvironment. Experimental Design: We describe in vitro effects of targeting of Jagged1 on ovarian cancer cells and in vivo effects of independent targeting of stromal and malignant cell...
متن کاملTargeting Tumor Stroma: Exploiting Apoptotic Priming
Difficulties in directly targeting tumor cells. Specific therapeutic targeting of cancer cells has been the holy grail of oncological research for decades. However, effective cancer cell directed therapy has proven difficult to achieve mainly due to the enormous multitude of genetic aberrations in many types of cancer. Given the vast number of inter-individual genetic variations and biologic be...
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ژورنال
عنوان ژورنال: Modern Research in Dentistry
سال: 2019
ISSN: 2637-7764
DOI: 10.31031/mrd.2019.04.000586